Researchers have been conducting tests on treating Erectile Dysfunction through the application of Sildenafil cream to different groups of men.
Strategic Science and Technologies is developing a series of studies on using Sildenafil Cream, also known as SST-6006, as an alternative to the oral Sildenafil (Viagra) or Rx-only chewable tablets such BlueChew. Sildenafil cream has an active ingredient of 5% Sildenafil Citrate.

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Erectile Dysfunction affects 20% of men with ages more than 20 (1). The cases have projected an increase to 322 million men by 2025.
While the market introduced Sildenafil more than a decade, researchers are still developing its effectiveness as a PDE-5 inhibitor in creams
Sildenafil Cream vs. Placebo Creams: ED Treatment Development
Researchers and developers introduced several ED treating creams to treat ED. 21 out of 36 men have reported satisfactory penile responses in applications using placebo creams (2).
These topically applied creams have active ingredients of aminophylline, isosorbide dinitrate, and co-dergocrine mesylate.
SST has completed the second phase of its studies conducted on men aged 18 to 70 years old.
While it hasn’t published the results yet in the U.S. National Library of Medicine, its outcome measures show Grade 3 and Grade 4 erection among patients compared to patients who used placebo cream for 60 minutes (3).

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During the first phase of the study, it concluded a 60% penile erection in patients within 60 minutes compared to patients who used placebo cream (3).
Sildenafil Cream vs. Sildenafil Oral
The primary purpose of developing this product is to minimize the effects of Sildenafil Citrate oral intake. Applying creams only on the penis may reduce the vasodilatory effects of Sildenafil on men.
Phase one of the studies shows a reduction of 20 times side effects based on a dosage of 50mg of Sildenafil tablets.
The vasodilatory effects of Sildenafil remain only on the affected area. It doesn’t have to pass through the bloodstreams inside the body.
What to Expect When Sildenafil Is Taken Through Application?
Users could acquire fewer complications in their health. With Sildenafil’s reduced access to the circulatory system, it could decrease the possibilities of certain diseases.
- Heart attack
- High blood pressure
- Stroke
Using the cream version lessens the symptoms of:
- Dizziness
- Sudden fainting
- Chest, jaw, or arm pains
- Nausea
- Light sensitivity
Avoid the possibility of losing sight or hearing when using the cream version of Sildenafil.
Another benefit of the application-only drug is it only lasts for sixty minutes. Oral intake lasts for up to 4 hours. It means that you only have to carry its effects on your body for up to 60 minutes.
Downsides
- Although its effectiveness is as strong as the pills, sexually active men may enjoy this for a short time.
- Because of its limited studies, usage is limited to persons only allowed to take its pill version. People who have premedical conditions must consult their physicians first. The previous study was conducted on healthy men without premedical disorders or conditions (3).
Conclusion
In general, the idea of using the cream version is better than taking it in tablets. Sildenafil cream has the same effectiveness as the oral version.
Applying Sildenafil cream can be healthier when carried only in the penis area. Maximize the effectiveness of Sildenafil cream in a short time and reduce complications.